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We aim to exploit next-generation DNA sequencing to better understand how medically important bacteria cause disease, become resistant to antibiotics and disseminate globally. Our major focus is the role of mobile genetic elements in the evolution of virulence and antimicrobial resistance amongst pathogens such as Escherichia coli, Streptococcus pyogenes, and Pseudomonas aeruginosa. Our group develops new computational approaches for the rapid analysis of bacterial genome data from the latest sequencing technologies.